(230215-bioRxiv) A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation - P1
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately😕. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell-fate in colorectal cancer (CRC), we performed a systematic single-cell analysis of 1,071 colonic organoid cultures regulated by…

